Senior Clinical Scientist

Mammoth Biosciences

Mammoth Biosciences

Brisbane, CA, USA

Posted on Apr 22, 2026

OPPORTUNITY

Mammoth Biosciences seeks an experienced Senior Clinical Scientist to advance pre-clinical research into clinical trials. This role encompasses both tactical and strategic responsibilities, including the design and execution of clinical trials, as well as meticulous monitoring of data for accuracy and integrity to ensure regulatory compliance. The incumbent will collaborate closely with the medical monitor, operations team, CRO partner, and study sites to ensure an efficient recruitment and follow-up of subjects in accordance with study protocols. Reporting to the VP, Clinical Development, the Senior Clinical Scientist will be responsible for the compilation and analysis of study data for various internal and external reports, as well as for key meetings.

KEY RESPONSIBILITIES

    • Trial Design and Execution: participate in protocol development, develop study CRFs, ICFs and databases

    • Data Analyses and Monitoring: monitor clinical trial data for accuracy and integrity

    • Compliance: ensure all study activities adhere to regulatory and ethical guidelines

    • Collaboration: act as a bridge between medical monitor, operations, CRO and study sites to ensure efficient communications, subject recruitment and trial management

    • Reports: write study reports, plans, and make data presentations for internal and external meetings

    • Other duties as assigned

REQUIRED QUALIFICATIONS

    • Master’s degree/PharmD/PhD in a relevant life science field

    • Minimum of 5 years experience in the pharmaceutical or biotechnology industry, with at least 2 years experience in clinical science/clinical development

    • Demonstrated experience in the design, execution, and reporting of global Phase 1-3 clinical trials

    • Strong proficiency in data analysis, interpretation of clinical trial results, and presenting data

    • Deep knowledge of Good Clinical Practice (GCP), ICH guidelines, and global regulatory requirements for clinical trials (FDA, EMA, etc.)

    • Excellent verbal, written, and presentation skills with proven ability to communicate with multiple stakeholders

    • Ability to travel internationally for site visits as needed

PREFERRED QUALIFICATIONS

    • Experience managing or directly overseeing clinical monitoring and data management processes

    • Prior experience in a clinical scientist role within a high-growth, fast-paced biotechnology environment

    • Demonstrated success in leading cross-functional teams and managing external partners (CROs)

    • Strong collaborator with strategic planning and independent problem-solving skills

    • Experienced in patient safety guidelines

    • Knowledgeable about clinical trial ethics and regulatory standards

    • Strong follow-up skills

    • Ability to manage multiple conflicting priorities

BENEFITS

    • Company-paid health/vision/dental benefits

    • Unlimited vacation and generous sick time

    • Company-sponsored meals and snacks

    • Wellness, caregiver and ergonomics benefits

    • 401(k) with company matching

COMPANY

Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.
It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.
Mammoth Biosciences requires that all employees be vaccinated against COVID as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.

142000 - 178000 USD a year

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