Project Team Lead

Janux Therapeutics

Janux Therapeutics

Administration

San Diego, CA, USA

USD 260k-280k / year + Equity

Posted on Apr 2, 2026

Janux Therapeutics is seeking a Project Team Leader (PTL) to provide visionary leadership and strategic direction for the development and execution of Integrated Asset Plans across our oncology and autoimmune portfolio. The PTL will serve as the single point of accountability for the seamless delivery of project milestones and outcomes for one or more assets, guiding them from First-in-Human/First-in-Patient (FIH/FIP) studies through Phase 1–3 clinical development and comprehensive life-cycle management.

This role requires a leader with exceptional expertise in oncology drug development, a proven ability to drive cross-functional teams, optimizing team alignment, governance, and overall team health. The PTL will be entrusted with critical oversight of asset budgets, investment recommendations, and continuous optimization of asset strategies, ensuring alignment with Janux’s broader portfolio objectives.

ESSENTIAL FUNCTIONS AND RESPONSIBILITIES

    Strategy and Execution

  • Architect and execute comprehensive lifecycle strategies and franchise plans that maximize the value of each asset for patients, physicians, payors, and Janux as an organization.
  • Ensure alignment with corporate objectives and deliver sustained impact across the portfolio.
  • Lead or co-lead asset-based development partnerships and alliances, leveraging external and internal expertise to accelerate innovation and achieve program goals.
  • Create and communicate a compelling vision for designing, conducting, and executing innovative clinical development plans.
  • Develop and contribute to overall strategy for specific diseases/indications, ensuring a franchise-wide portfolio perspective.
  • Provide strategic insights and recommendations to optimize clinical development plans.

    • Drug Development Experience

  • Anticipate and proactively address challenges across the development continuum, including risk assessment, mitigation planning, and adaptation to evolving regulatory and competitive landscapes.
  • Collaborate closely with Clinical Development, Regulatory Strategy, and Clinical Operations to deliver high-quality drug approval applications, ensuring successful regulatory outcomes and market access.
  • Collaborate with cross-functional teams to continuously refine clinical strategies, leveraging translational science, real-world evidence, and stakeholder feedback to optimize program outcomes.

    • Leadership and Matrix Management

  • Lead and develop a cross functional Asset Team comprised of Clinical Development, Statistics, Clinical Pharmacology, Translational Oncology, Regulatory, Commercial Development, Safety, Project Management, Operations, Pharmaceutical Sciences and other functions as determined by the organization’s needs.
  • Foster an effective, ethical, and inclusive culture that encourages teamwork, peer review, cooperation, and continuous improvement.
  • Champion diversity of thought, accountability, integrity, and process excellence.
  • Oversee team budget and headcount, ensuring optimal resource allocation.

    • Stakeholder Engagement and Communication

  • Collaborate closely with leaders in Research, Development, Regulatory, and other key functional areas.
  • Build and maintain relationships with external leaders, physicians, and patient advocacy groups.
  • Be recognized internally and externally as an expert in the field, representing the organization at speaking engagements and industry forums.
  • Perform other duties as assigned.

EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS AND ABILITIES

  • PhD, PharmD, MD, or other advanced degree preferred.
  • 10+ years of extensive clinical trial, drug development, and regulatory experience, with a strong scientific background.
  • Demonstrated ability to lead through influence, managing project teams in a matrix environment rather than direct line management.
  • Significant clinical development experience and exposure to different therapeutic modalities. Oncology and autoimmune experience are highly desirable.

    • Travel Requirements

    • Domestic and international travel may be required.
Job Type: Full-time
Benefits:
· Annual bonus program
· Incentive stock option plan
· 401k plan with flat non-elective employer contribution
· Comprehensive medical insurance with 90-100% employer-paid premiums
· Dental and vision insurance
· HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity)
· Unlimited PTO
· Generous holiday schedule; includes summer and winter company shutdown
· Relocation assistance
Schedule:
· Monday to Friday
Work authorization:
· United States (Required)
Additional Compensation:
· Annual targeted bonus %
Work Location:
· On site (San Diego, CA)
EQUAL OPPORTUNITY EMPLOYER:
Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.
Notice to Recruiters and Third-Party Agencies
The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.

260000 - 280000 USD a year

In addition to a competitive base salary ranging from $260,000 to $280,000, we offer stock options, restricted stock units, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.

Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, internal equity and work location.

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