Clinical Biomarker Lead
Janux Therapeutics
San Diego, CA, USA
USD 150k-163k / year + Equity
Posted on Jan 16, 2026
Janux Therapeutics is seeking a Clinical Biomarker Lead to join our Translational group and contribute hands-on in the development and execution of biomarker analysis plans and data analytics strategy for our early-stage oncology programs. This individual will develop critical insights from clinical trial data to inform strategic decision-making across Janux’s early phase portfolio. The ideal candidate will bring an in-depth understanding of solid tumor immunology and clinical-translational research experience.
ESSENTIAL FUNCTIONS AND RESPONSIBILITIES
- Lead internal biomarker data analysis efforts to support Janux’s oncology and autoimmune pipeline.
- Perform high throughput data analytics of pre-clinical, translational, and clinical datasets to identify and validate potential biomarkers of response/resistance to TRACTr, TRACIr, and/or ARM treatments.
- Integrate functional biological readouts with patient’s clinicopathological features to contribute to patient selection strategies for clinical programs.
- Identify, develop, and validate translational and clinical biomarker assays including Pharmacokinetics, immunogenicity (ADA and NAb assays), Pharmacodynamics, and predictive.
- Manage multiple CROs and maintain strong oversight on deliverables (proposals, timelines, experimental design, data analyses and reporting).
- Prepare and present data. Collaborate with Biomarker and Translational teams to evaluate data analytic approaches and ensure meaningful insights in the delivery.
- Perform in-depth scientific literature review to help address critical questions relating to target biology, clinical relevance, and associated assays.
- Work cross-functionally with Research, Clinical and CMC teams to drive scientific programs and deliver critical insights to help inform decision-making across the portfolio.
EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS AND ABILITIES
- Ph.D. in Bioinformatics, Computational Biology, Immunology, or related scientific discipline with 4+ years of experience, preferably in an industry setting, with an emphasis in biomarker analysis or translational medicine.
- Strong understanding and experience working in immuno-oncology and/or solid tumor oncology with hands-on experience in designing, developing, and interpreting biomarker analysis.
- Proficiency in coding skills (e.g., R, Python) and strong working knowledge of bioinformatics databases and tools.
- Demonstrated ability to create impactful data visualization outputs and present meaningful insights.
- Experience with Good Clinical Practice (GCP) principles and studies transitioning into clinical trials.
- Competence in data analysis tools (Excel, GraphPad, R, Python).
- Experience working with external CROs (due diligence, proposals, oversight, project management, data analyses, and reporting) is highly preferred.
- Strong analytical and critical thinking skills with the ability to work in a fast-paced environment. Excellent written and oral communication skills.
Job Type: Full-time
Benefits:
· Annual bonus program
· Incentive stock option plan
· 401k plan with flat non-elective employer contribution
· Comprehensive medical insurance with 90-100% employer-paid premiums
· Dental and vision insurance
· HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity)
· Unlimited PTO
· Generous holiday schedule; includes summer and winter company shutdown
· Relocation assistance
Schedule:
· Monday to Friday
Work authorization:
· United States (Required)
Additional Compensation:
· Annual targeted bonus %
Work Location:
· On site (San Diego, CA)
EQUAL OPPORTUNITY EMPLOYER:
Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.
Notice to Recruiters and Third-Party Agencies
The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.
150000 - 163000 USD a year
In addition to a competitive base salary ranging from $150,000 to $163,000, we offer stock options, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.
Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, internal equity and work location.