We are looking for a motivated Associate Scientist to join our sgRNA screening team within the cross-functional Genomics and Computational Biology group. The sgRNA screening workflow is a critical step to nominate sgRNA candidates for most pipeline projects at Intellia. You will be part of a team responsible for testing sgRNAs in primary cells and immortalized cell lines, developing and executing cell and molecular biology assays to characterize genome editing outcomes. Additionally, you will collaborate with multiple groups such as Delivery Sciences and Gene Editing Platform to test novel delivery modalities and genome editing tools. In this role, you will:

Duties/Responsibilities

List the essential job duties that are specific to the position.

• Isolate, culture and/or bank primary cells and/or immortalized cell lines
• Transfect, transduce and/or electroporate cultured cells with genome editing reagents
• Develop, optimize and execute routine cell viability, mRNA and protein expression assays
• Quantify on- and off-target genome editing outcomes using various methods such as amplicon sequencing and ddPCR
• Work with team leads to ensure project timelines are met
• Record data in an electronic lab notebook and assist in intellectual property fillings
• Interpret findings and provide input to various projects
• Present updates in team meetings

Supervisory Responsibilities

• None

Requirements

Skills/Abilities

• Excellent verbal and written communication skills.
• Excellent interpersonal skills.
• Excellent organizational skills and attention to detail.
• Excellent time management skills with a proven ability to meet deadlines.
• Strong analytical and problem-solving skills.
• Ability to function well in a high-paced environment

Education / Certifications

• BS or MSc degree in Biology or related disciplines

Experience

• BS or MSc degree in Biology or related disciplines with 4+ years (BS degree) or 2+ years (MS degree) of industry experience is required
• Extensive experience with cell culture and molecular biology assays is required
• Experience with primary hepatocytes and/or primary hematopoietic stem and progenitor cells is strongly preferred
• Hands-on experience with Illumina library construction, quantification, sequencing, and data QC is preferred
• Experience with liquid handling automation systems is preferred

Physical Requirements

Prolonged periods of sitting

#LI-Onsite

Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, are expected to follow all applicable federal, state, and local public health regulations and guidelines, and are strongly encouraged to follow all public health recommendations, including being vaccinated for COVID-19.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Applications are accepted on a rolling basis, and will continue to be accepted until the position is filled at which point the position will be taken down.

The base salary for this position is expected to range between $103,500.00 - $126,500.00 USD per year.

The salary offered is determined based on a range of factors including, but not limited to, relevant education and training, overall related experience, specialized, rare or in-demand skill sets, internal comparators and other business needs. Upon joining Intellia, your salary will be reviewed periodically and additional factors such as time in role and performance will be considered. Intellia may change the published salary range based on company and market factors.

Additional compensation includes a performance-based annual cash bonus, a new hire equity grant, and eligibility to be considered for annual equity awards the value of which are determined annually at the Company’s discretion.

For more information about Intellia’s benefits, please click here.