Senior Bioinformatics Engineer

Helix

Helix

Other Engineering

Remote

USD 134k-179k / year + Equity

Posted on Apr 23, 2026
Senior Bioinformatics Engineer
United States - Remote
Bioinformatics
Remote
Full-time
Who We Are & What We Do
At Helix, our mission is simple: to help everyone improve their lives through their DNA.
Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics.
What is special about this role?
As a Senior Bioinformatics Engineer, you will be working with a team of talented bioinformatics engineers and scientists to create and maintain bioinformatics pipelines to advance Helix’s mission. You will play a leading role in designing and implementing reliable and innovative solutions in a highly regulated environment.
As a Senior Bioinformatics Engineer, you will:
  • Develop, maintain, and document bioinformatics pipelines in a regulated environment.
  • Architect and maintain supporting infrastructure in AWS.
  • Analyze and generate data insights to support the development and improvements of existing and new bioinformatics algorithms.
  • Design and develop test cases and test scripts.
  • Contribute to the creation and maintenance of regulatory documentation as part of the design control process.
About you:
  • B.S. or M.S. Technical Degree (e.g. Computer Science, Bioinformatics or similar).
  • 3 years of relevant industry experience.
  • Experience with developing NGS bioinformatics pipelines.
  • Proficiency with Python.
  • Experience with Cloud computing environment.
  • Strong communication skills, both oral and written.
  • Open to learning new skills and not afraid to step outside of the comfort zone.
Pluses:
  • Experience with software development under CLIA/CAP regulations and/or FDA regulations is a big plus.
  • Experience writing test cases and test scripts.
  • Experience with Jira and JAMA.
  • Experience with Claud Code and development with AI.
Expected Interview Process:
1) Recruiter Screen 2) Manager Screen/Tech Screen 3) Onsite 4) Offer
Expected Pay For This Role:
There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity
  • Expected Helix Base: $134,000 - $179,000
  • Expected Helix Discretionary Annual Bonus: 10% of your annual salary
  • Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model.
Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits:
  • Comprehensive Health Insurance with Date of Hire eligibility
    • Above average employer paid premium coverage
  • 12 weeks Helix Paid Parental Leave option
  • 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire
  • Comprehensive Well-Being Benefits
  • Flexible PTO
  • Remote options for many roles and a home office stipend
What To Expect During Your First 90 days:
  • First 30 days: you’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U.
  • Day 30 - 60: you’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities.
  • Day 60 - 90: you’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission.
Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws.
#LI-Remote

Compensation

The base pay range for this role is $134,000 – $179,000 per year.
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Req ID: R780
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