Senior Research Scientist
Helix
United States · Remote
USD 138k-183k / year + Equity
Posted on Oct 11, 2025
Senior Research Scientist
United States - Remote
Research
Remote
Full-time
Who We Are & What We Do
At Helix, our mission is simple: to help everyone improve their lives through their DNA.
Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics.
What is special about this role:
The mission of the Helix Research team is to conduct, facilitate, and publish cutting-edge genomics research, especially in relation to health outcomes. We collaborate with clinical, healthcare, and life science partners on clinically-relevant population-based genomic studies. We typically combine genomic data (Helix Exome+Ⓡ) with phenotypic clinical information obtained systematically from EHRs and medical claims, through collaboration with physicians at our health system partners, via biomarkers (such as proteomics and laboratory tests), as well as other modalities (self-reported data, wearables). We believe that everyone will be sequenced as part of routine medical care in the not-too-distant future, and our fast and nimble team helps generate the evidence to turn that faith into fact.
As a Senior Research Scientist, you will:
- Push genomic medicine forward by assessing clinical impact and utility of polygenic risk scores, pharmacogenomics, HLA types, rare variants, CNVs and other genomic applications in various health conditions across large, diverse population cohorts
- Organize and parse various types of medical data (EHR codes, notes, imaging, biomarkers, self-reported data) into rich phenotypes for analysis
- Work collaboratively with internal and external teams, including our health system partners, to conduct research on genomic and phenotypic data to replicate published studies in new cohorts and discover novel associations
- Communicate your findings internally to key stakeholders and externally to partners and scientific peers at conferences and in publications
- Have the opportunity to shape how Helix partners think about and integrate genomics into their business model and clinical care pathways
About you:
- An MD or PhD in genomics, medical informatics, bioinformatics, biostatistics, epidemiology or a related field, plus post graduate experience
- Experience with analysis of large human genomic datasets, such as UKBiobank, All of Us, TOPmed, etc. using open-source bioinformatics tools / packages (Python, R, Hail, PLINK, etc.)
- Experience parsing real world evidence (RWE) from claims, electronic health records, registries, biobanks.
- Outstanding communication skills as well as broad research interests that will enable them to facilitate interactions between clinicians, bioinformaticians, scientists, and business and learn new areas easily.
- Fluent in English
- Strong programming and scripting abilities in languages (Python, R, SQL, etc).
- Entrepreneurial spirit -- eager to jump in, define, and refine projects as needed
Pluses:
- Strong publication record
- Working knowledge of OMOP and/or other CDM
- Experience working with cloud-based analytical platforms (AWS, etc.)
- Experience working with health systems, payers, diagnostic testing
- Experience with remote teams/consortia/group collaborations
- Experience with Health Economics and Outcomes Research
- Experience with LLMs or AI
Expected Interview Process:
1) Recruiter Screen 2) Manager Screen/Tech Screen 3) Onsite 4) Offer
Expected Pay For This Role: $138,000 - $183,000
There are 3 distinct parts to your Helix offer: 1) Base Salary 2) Annual Bonus 3) Equity
- Expected Helix Base:
- Expected Helix Discretionary Annual Bonus: 10% of your annual salary
- Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model.
Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits:
- Comprehensive Health Insurance with Date of Hire eligibility
- Above average employer paid premium coverage
- 12 weeks Helix Paid Parental Leave option
- 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire
- Comprehensive Well-Being Benefits
- Flexible PTO
- Remote options for many roles and a home office stipend
What To Expect During Your First 90 days:
- First 30 days: you’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U.
- Day 30 - 60: you’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities.
- Day 60 - 90: you’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission.
Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws.
#LI-Remote
First name *
Last name *
Email *
LinkedIn URL
Resume *
Click to upload or drag and drop here
Voluntary Self-Identification
To comply with government reporting requirements, we invite candidates to participate in the self-identification survey below. Your completion of this form is entirely optional, and your decision will neither influence the hiring process nor any subsequent stages. Any information you choose to share will be kept confidential and stored in a secure file. As outlined in our Equal Employment Opportunity policy, we uphold a commitment to non-discrimination based on any protected group status specified in applicable laws.
Gender
Race
Race and ethnicity descriptions
Voluntary Self-Identification of Veteran Status
VEVRAA requires Government contractors to take affirmative action to employ and advance in employment protected veterans. To help us measure the effectiveness of our outreach and recruitment efforts of veterans, we are asking you to tell us if you are a veteran covered by VEVRAA. If you believe that you belong to any of the following categories of protected veterans, please indicate by making the appropriate selection.
Veteran status descriptions
Disabled veteran
A veteran who served on active duty in the U.S. military and is entitled to disability compensation (or who but for the receipt of military retired pay would be entitled to disability compensation) under laws administered by the Secretary of Veterans Affairs, or was discharged or released from active duty because of a service-connected disabilityRecently separated veteran
A veteran separated during the three-year period beginning on the date of the veteran's discharge or release from active duty in the U.S military, ground, naval, or air serviceActive duty wartime or campaign badge veteran
A veteran who served on active duty in the U.S. military during a war, or in a campaign or expedition for which a campaign badge was authorized under the laws administered by the Department of DefenseArmed Forces service medal veteran
A veteran who, while serving on active duty in the U.S. military ground, naval, or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985 (61 Fed. Reg. 1209).Veteran status
PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.
By applying you agree to Gem's terms and privacy policy.
Save your info to apply to other roles faster & help employers reach you.
Req ID: R741